Apoptosis is the process of programmed cell changes and death that may occur in multicellular organisms. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis generally confers advantages during an organism’s life cycle. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage. Research in and around apoptosis has increased substantially since the early 1990s. Fat cells are vulnerable to the effects of selective heating. Their initial evidence, published in Lasers in Surgery and Medicine in 2013, concluded that controlled local tissue heating can induce selective fat cell reduction and subsequent loss of subcutaneous fat without damaging other tissue layers. This led to the development of the patented selective RF technology behind the non-invasive Vanquish procedure.